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Showing posts from July, 2023

RAMPART TRIAL-Rapid Anticonvulsant Medication Prior to Arrival Trial

The RAMPART Trial Status epilepticus is a life-threatening medical emergency that occurs when a seizure lasts for more than 5 minutes or when there are multiple seizures without a return to consciousness in between . It is important to treat status epilepticus as quickly as possible, as the longer it goes untreated, the greater the risk of brain damage and death. The RAMPART trial (Rapid Anticonvulsant Medication Prior to Arrival Trial) was a randomized clinical trial that compared the efficacy of intramuscular (IM) midazolam to intravenous (IV) lorazepam in the prehospital treatment of status epilepticus. The trial enrolled 1,080 adults and children with status epilepticus who were treated by paramedics. The primary outcome of the trial was the proportion of patients who had seizure cessation within 10 minutes of receiving the first dose of medication. The secondary outcomes included the proportion of patients who had seizure cessation within 20 minutes, 30 minutes, and 60 minutes of