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CRASH-3 TRIAL (Tranexamic Acid in Head Injury)













 

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SALSA Trial

The "Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia:  The SALSA Randomized Clinical Trial" published in JAMA, is a significant clinical trial that specifically investigated the use of slow continuous infusion therapies of hypertonic saline with fast bolus replacement, for patients with symptomatic hyponatremia.  Background:   Symptomatic hyponatremia is a condition in which patients have low sodium levels in the blood, leading to neurological symptoms and potentially life-threatening complications. Rapid correction of sodium levels is necessary in such cases to alleviate symptoms and prevent harm. Objective:   The SALSA trial aimed to assess the efficacy and safety of two different strategies for correcting symptomatic hyponatremia using hypertonic saline solutions.  Methods: The study was a randomized clinical trial involving patients with symptomatic hyponatremia. Participants were divided into two groups:  Bolus Therapy G
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